Rajiv Gandhi University of Health Sciences, Karnataka
I Year B.Pharm Degree Examination – 10-Jan-2020
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Time: Three Hours Max. Marks: 70 Marks
PHARMACEUTICAL ORGANIC CHEMISTRY – I
(Revised Scheme 3)
Q.P. CODE: 2604
Your answers should be specific to the questions asked
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Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- Explain the reactivity and orientation in electrophilic aromatic substitution with a note on activating and deactivating groups.
- Explain the following
- Diazotisation and its applications.
- Basicity of amines.
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- Explain the mechanism of
- Free radical chain reaction
- Anti-Markovnikov's rule
SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
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- Write three methods of preparation of cycloalkanes.
- Explain: Saytzeff's rule and Hoffmann's elimination.
- Explain theory of strainless ring and molecular orbital concept in cyclohexane.
- Discuss factors affecting SN1 and SN2 reactions.
- Explain 1,2 and 1,4 addition mechanism with example.
- Explain mechanism of sulphonation of benzene.
- Discuss the effects of substituents on acidity of phenols.
- Explain Cannizzaro reaction and crossed Cannizzaro reaction with examples.
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SHORT ANSWERS 10 x 2 = 20 Marks
- What are protic and aprotic solvents? Give examples.
- Define carbenes with structures.
- State Huckel's rule.
- What happens when toluene is nitrated, write reaction?
- Write reaction: n-butyl alcohol is treated with a mineral acid.
- Write the structures and IUPAC names of a) Glycerol b) Neopentane.
- What is Reimer-Tiemann reaction? Write reaction.
- Define a) nucleophile b) electrophile.
- Explain: keto enol tautomerism.
- How do you convert, Carboxylic acid to anhydride?
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